Scindy Pharmaceutical’s next-generation in vivo lipid nanoparticle technology integrates novel targeted delivery strategies while building on traditional methods. Our in vivo NeoLNP™ technology precisely controls the in vivo distribution of lipid nanoparticles (LNPs) through innovative lipid formulations and personalized targeting ligand designs, achieving accurate and efficient RNA delivery.

The in vivo NeoLNP™ RNA Local Transfection Kit (SDR8003) is a ready-to-use RNA local delivery solution. Leveraging proprietary LNP in vivo targeted delivery technology, SDR8003 effortlessly meets the transient encapsulation needs of siRNA, miRNA, sgRNA, mRNA, and other RNA types. Through diverse administration routes, it precisely delivers RNA to the administration site, providing a flexible, controllable, and highly reliable RNA local targeted delivery solution for cutting-edge research, empowering researchers to tackle gene editing and regulation challenges.

Compatible with Multiple RNA Types:

Suitable for delivering siRNA, gRNA, mRNA, circRNA, and more.

SDR8003: Precise Delivery, High Efficiency

Diverse Injection Methods, Direct Targeting: SDR8003 overcomes traditional delivery limitations, supporting multiple injection methods to precisely deliver RNA to target tissues or organs.

Flexible Administration, Multi-Scenario Applicability: SDR8003 offers highly flexible administration routes, customizable to meet diverse research goals, from vaccine development to gene regulation studies.

Localized Focus, High Enrichment: With superior local delivery capabilities, SDR8003 concentrates over 90% of mRNA or siRNA at the injection site, enhancing RNA concentration in target tissues, improving therapeutic or research outcomes, and minimizing distribution in non-target areas to reduce potential side effects.

Distinct Features, Precise Positioning: SDR8003 effectively prevents RNA diffusion to other organs and tissues, ensuring precise delivery, minimizing interference with non-target tissues, and reducing systemic side effects, critical for personalized and precise treatments in precision medicine and gene therapy.

Intratumoral Injection (IT) - High Expression in Solid Tumor Tissue:

▲ Intratumoral injection of Fluc-mRNA (10µg/mouse), 6-hour distribution.

▲ Intratumoral injection of Fluc-mRNA (10µg/mouse), 6-hour tissue distribution shows 98% fluorescence in tumor tissue.

Intramuscular Injection (IM) - mRNA:

Intramuscular injection of Fluc mRNA (10µg/mouse), 6-hour fluorescence shows 97% expression in muscle tissue, with minimal expression in other organs (heart, liver, spleen, lungs, kidneys).

Intramuscular Injection (IM) - siRNA:

▲ Intramuscular injection of Cy5-siRNA (10µg/mouse), 3-hour

Intramuscular injection of Cy5-siRNA (10µg/mouse), 3-hour tissue distribution shows 93% siRNA accumulation in muscle, with minimal distribution to other organs.

Intradermal Injection (ID):

▲ Intradermal injection of Fluc mRNA (6µg/mouse), 6-hour

Intradermal injection of Fluc mRNA (6µg/mouse), 6-hour tissue distribution shows 97% mRNA expression in the skin, with minimal distribution to other organs.

Safety:

● Uses biodegradable lipid materials with excellent biocompatibility.

● Free of ethanol, avoiding hemolysis, neurotoxicity, or vascular irritation.

● Low off-target effects, with RNA concentrated at the injection site, reducing toxicity and side effects in non-target organs.

Why Choose in vivo NeoLNP™ Transfection Kit?

● Efficient: Maintains stable high transfection levels regardless of injection method.

● Flexible: Customizable for systemic or localized RNA delivery based on research goals.

● User-Friendly: Optimized delivery solutions enable rapid, efficient RNA encapsulation, simplifying experiments.

With the in vivo NeoLNP™ Transfection Kit, researchers can flexibly utilize multiple delivery routes to achieve precise RNA delivery, meeting unique research needs. From broad systemic applications to highly specific organ-targeted delivery, this kit is a powerful tool for cutting-edge RNA research.

Ready-to-Use LNP In Vivo Delivery Technology

The in vivo NeoLNP™ Kit stands out for its rapid and efficient RNA encapsulation capabilities. Compared to traditional methods, it requires no complex equipment, achieving efficient encapsulation through simple mixing with RNA solutions, significantly reducing preparation time. This innovation enhances RNA stability and ensures efficient transfection, offering a new transfection experience compared to traditional liposome-based nucleic acid adsorption methods.